The adrenal glands are a pair of endocrine glands situated right above the kidneys. They are responsible for producing stress hormones such as the cortisol and adrenaline for maintaining your blood pressure and your body response to stress. Adrenal over-secreting (hyper-functioning) or under-secreting hormones (hypo-functioning) are well recognized clinical syndromes and warrant medical treatment. Recently the term adrenal fatigue has received much attention. Adrenal fatigue is a term applied to a constellation of nonspecific symptoms, such as lethargy, body aches, nervousness, and the term has turned up very much in lifestyle magazines and on alternative medicine websites. But does such an entity of adrenal fatigue really exist? This article from Mayo-clinic aptly summarizes the issues surrounding adrenal fatigue.